Reference centres

Where you are treated matters.

In a tumour as complex as glioblastoma, the experience of the centre and the multidisciplinary team can change your outcome. Here's what to look for and how to get referred.

Important context. As of today, Spain has no formally designated CSUR (Reference Centre) specifically for brain tumours. Hospitals that treat them well exist, but they lack official recognition. This makes it even more important that you know what to look for.
What to look for

Criteria for choosing a centre

Not all hospitals have the same experience, technology or access to clinical trials. These are the questions that matter:

Multidisciplinary neuro-oncology committee

A committee where neurosurgeons, neuro-oncologists, radiation oncologists, neuropathologists and neuroradiologists meet regularly to discuss each case. This is the gold standard: it ensures no single specialist decides alone.

Ask: Does your hospital have a brain tumour committee? How often does it meet?

Volume of cases

Centres that treat more brain tumours per year accumulate more experience. There is no magic number, but the difference between a centre that sees 10 glioblastomas a year and one that sees 80 is substantial.

Ask: How many brain tumour cases does the centre treat per year?

Surgical technology

Intraoperative MRI (iMRI), awake surgery with cortical mapping, neuronavigation, intraoperative ultrasound and 5-ALA fluorescence help maximise safe resection. Not every hospital has all of them.

Ask: What surgical tools does the operating room have? Does the surgeon use 5-ALA?

Molecular diagnosis

At minimum, the centre should perform NGS sequencing, MGMT methylation analysis and IDH testing. Ideally it should also offer a methylation profile and RNA-seq, or send the sample to a centre that does.

Ask: What molecular tests does the centre perform? Can the sample be sent elsewhere if needed?

Active clinical trials

A centre that participates in clinical trials offers access to treatments that are not otherwise available. This is especially important in glioblastoma, where standard options are limited.

Ask: Does the centre have open trials for glioblastoma? Which ones?

Search trials by hospital

TTFields availability

Since 2025, TTFields are funded by the NHS within a monitoring study. Not all hospitals are designated to administer them. If yours isn't, it's a reason to request referral.

Ask: Is this hospital designated for TTFields? If not, where is the nearest one?

Hospitals with neuro-oncology programmes

Known centres in Spain

This is an informational list of hospitals known to have neuro-oncology units, brain tumour committees or active clinical trial programmes. It is not a ranking, nor an endorsement. The fact that a hospital doesn't appear here doesn't mean it lacks quality, and appearing here doesn't guarantee it meets all the criteria above. Always verify directly.

This list is being compiled and will grow. If you know of a hospital with a neuro-oncology programme that should be here, write to us.

Madrid

Hospital Universitario 12 de Octubre Unidad Multidisciplinar de Neurooncología (UMNO). CSUR de neurocirugía compleja. Participa en ensayos clínicos internacionales. Investigación neurooncológica con el CNIO.
Hospital Clínico San Carlos Área de neurooncología. Experiencia destacada en TTFields. Participó en el ensayo clínico de aprobación del dispositivo.
Hospital Universitario Ramón y Cajal Servicio de oncología médica con programa de neurooncología. Participa en ensayos del grupo GEINO.
Clínica Universidad de Navarra (sede Madrid) Centro privado. RM intraoperatoria de alto campo. Ensayos clínicos propios. Equipo multidisciplinar con más de 15 años de experiencia.

Cataluña

Hospital Universitari Vall d'Hebron Considerado centro de referencia de facto para tumores cerebrales en España. Colaboración con el VHIO para terapias innovadoras y vacunas tumorales.
Institut Català d'Oncologia (ICO) Sedes en L'Hospitalet, Badalona (Germans Trias) y Girona. Programa de neurooncología activo con ensayos clínicos del grupo GEINO.
Hospital Clínic de Barcelona Servicio de oncología con línea de neurooncología y participación en ensayos clínicos multicéntricos.
Hospital del Mar Participa en ensayos clínicos multicéntricos para glioblastoma.

Andalucía

Hospital Universitario Virgen del Rocío (Sevilla) Servicio de neurocirugía y oncología con participación en ensayos multicéntricos de glioblastoma.
Hospital Regional Universitario de Málaga Programa de neurooncología. Participación en ensayos clínicos internacionales.

Comunidad Valenciana

Hospital Universitario y Politécnico La Fe (Valencia) Servicio de neurooncología con participación en ensayos clínicos multicéntricos.

Navarra

Clínica Universidad de Navarra (Pamplona) Centro privado. RM intraoperatoria de alto campo. Área de Tumores del Sistema Nervioso Central. Investigación con virus oncolíticos en colaboración con el CIMA.

Castilla y León

Hospital Clínico Universitario de Salamanca Participación en ensayos clínicos multicéntricos de glioblastoma.

Baleares

Hospital Universitario Son Espases (Palma) Participación en ensayos clínicos multicéntricos.
Referral

How to get referred to another centre

If your hospital doesn't have the experience or resources you need, you have the right to be treated at one that does. There are two main pathways:

SIFCO: National referral between Autonomous Communities

The SIFCO system (Healthcare Information and Mutual Guarantee Fund) allows your medical team to refer you to a hospital of another region when your case requires resources that your community does not have. The costs are covered by your Autonomous Community.

  • Your specialist must initiate the request. If they don't propose it, you can request it.
  • The Autonomous Community authorises the referral and covers travel and accommodation expenses. Keep all invoices.
  • If your request is denied, you can appeal through the hospital's Patient Care Service.

Second opinion within your Autonomous Community

You have the right to request a second medical opinion from another specialist within your region. Procedures vary by community. Ask the hospital's Patient Care Service or your social worker.

Important: the right to a second opinion is limited to your own Autonomous Community. For referral to another region, use SIFCO.

If your hospital lacks key resources (neuro-oncology committee, molecular diagnosis, clinical trials, TTFields), that is a valid and strong reason to request referral. Don't settle. Your life may depend on it.

The right centre can make the difference. Ask, compare, insist.